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KMID : 0616120070380010027
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 1 p.27 ~ p.30
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(Inhibitory Activity on Monoamine Oxidase of Chrysanthemum indicum L.)
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Jang Eun-Ju
Hwang Keum-Hee
Park Tae-Kyu
Choi Dong-Guk
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Abstract
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We examined the inhibitory activities against monoamine oxidase (MAO) of Chrysanthemum indicum L. in vitro and in vivo methods. Methanolic extract of C. indicum showed significant inhibitory activities on MAO-A that were prepared from rat brain in vitro. The inhibitory activities were measured by serotonin as a substrate. The IC_{50} value of methanolic extract of C. indicum was 0.24 mg/ml for the inhibition of MAO-A. The ethylacetate fraction of methanolic extract of C. indicum exhibited the best activity toward MAO-A with IC_{50} value of 0.05 mg/ml in vitro. It was observed that those activities in vivo tests have different tendency each other. Ethanolic extract of C. indicum was have no effect on rat MAO by the oral administration (p<0.05). However, MAO inhibitory activities of ethanolic extract of C. indicum by the oral administration have similar tendency to those of iproniazid. Consequently, we suggest that C. indicum may have the effects on the inhibitory activities against MAO both in vitro and in vivo. These results indicates that the C. indicum extract has properties indicative of potential neuroprotective ability.
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KEYWORD
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monoamine oxidase (MAO), serotonin (5-HT), Chrysanthemum indicum
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